St Trinian's, the infamous school for 'young ladies', is once again facing dire financial crisis. The bank is threatening headmistress Camilla Fritton with closure. Meanwhile her unorthodox doctrine of free expression and self empowerment is also under threat from new Education Minister Geoffrey Thwaites. He may be an old flame of Camilla's, but right now he's determined to bring discipline and order to the anarchic school. But the St Trinian's girls are in a league of their own; smart, fearless and determined to defend the school they love to the end. They need to unite the warring girl gang cliques and come up witht he cash fast. Sassy head girl Kelly and newcomer Annabelle join forces and gather together a motley crew of teachers, the fiendishly charming Flash Harry and the resourceful and ruthless pupils to pull off the heist of the century. They're planning to steal the famous painting "Girl With A Pearl Earring" from the National Gallery right under the noses of the authorities. But can their combined cunning, girlish wiles and total lack of shame win the day before the authorities close them down for good? All of the hilarious antics and the girl-power action, which have made St Trinian's one of the greatest and best-loved national institutions, are back on the big screen.