Niles (Mehcad Brookes), Emily (Serinda Swan) and their friends head out on a road trip to New Orleans. The group decides to stop at a roadside convenience store owned by Chopper (Sid Haig), who tells them the tale of Lockjaw, a fabled god-like creature who is half-man, half alligator. Their curiosity peaked, the group decides to play along with the local tourist trap and journey deep into the backwoods to find the old dilapidated cabin, the supposed birthplace of the creature. As they set up camp for the night, their faith is put to the test when Lockjaw turns out to be more than just a myth and they realize the locals are hiding a horrifying secret that jeopardizes them all.